You could always add acetone, but I wouldn't recommend it. Having personally done this with an older truck, a Ram 1500 saw amazing results and seriously got about 5-6 mpg more, went from about 12 mpg at best to close to 20 sometimes. Didn't use it all the time and the truck already had a lot of miles on it, however within 6 months we did start noticing an oil leak. Related? More than likely.
What would I recommend? Start with the basics, check tire pressure, change the oil, clean out the air filter, replace the fuel filter and use the cruise control.
Did your buddy used to get better mileage and now its dropping, or is this the gas mileage he has always gotton with his Highlander?